Polyurethane-61

Synthetic
Skin Conditioner
Not Clean
OriginPolyurethane-61 is synthesized from polyols and isocyanates, which are petroleum-derived or bio-based chemical precursors. The polymer is produced through step-growth polymerization, where polyols and isocyanates react to form long-chain urethane linkages.
Polyurethane-61 is the complex polymer made by first reacting saturated methylene diphenyldiisocyanate (SMDI), dimethyl aminopropylamine (DMAPA), isopropylidenediphenoxypropanol and the polyester polyol derived from isophthalic acid/1,6-hexanediol/adipic acid to form a prepolymer, followed by dispersion in water with triethylamine and subsequent chain extension with ethylenediamine.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Nail Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Strengthens nails
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2017
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: CosIng · EWG · CIR