Polyurethane-65

Synthetic

Skin Conditioner

Not Clean

Polyurethane-65 is a complex urethane copolymer made by reacting Isophorone Diisocyanate (IPDI) with a combination of dimethylolpropionic acid (DMPA) and a copolymer composed of Neopentyl Glycol and Adipic Acid. The resulting polymer is chain extended with ethylene diamine and neutralized with trimethylamine

Functions

Nail Conditioning

A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.

Strengthens nails

Traditional Use

A synthetic polymer developed in the mid-20th century for industrial applications. Used in cosmetics as a film-forming agent and texture modifier in formulations like foundations and primers.

EWG

CIR

Safe as used

Pregnancy

Yes

CIR Safety Findings

Not a Sensitizer

medical-approval

all-shades-safe

Regulatory Status

USA✔ permitted

EU⚠ restricted

JAPAN⚠ restricted

CANADA⚠ restricted

Regulatory Agencies

EWG CIR FDA EU COSING Health Canada

Skin Types

●all-skin-types

Best For

General

Pregnancy & Breastfeeding Safe

Yes

The paper trail

🔬Peer-reviewednone on file

⚖️Regulatory1 listing →

🛡️Safety-assessed1 review →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

Verified Jun 2026

Data: CosIng · EWG · CIR