Polyurethane-65

Synthetic
Skin Conditioner
Not Clean
OriginPolyurethane-65 is derived from petrochemical sources, specifically isocyanates and polyols from the polyurethane polymer family. It is synthesized through the polymerization reaction between diisocyanates and polyols under controlled catalytic conditions.
Polyurethane-65 is a complex urethane copolymer made by reacting Isophorone Diisocyanate (IPDI) with a combination of dimethylolpropionic acid (DMPA) and a copolymer composed of Neopentyl Glycol and Adipic Acid. The resulting polymer is chain extended with ethylene diamine and neutralized with trimethylamine
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Nail Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Strengthens nails
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2017
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: CosIng · EWG · CIR