Proline

AKA: L-proline, 147-85-3, L-(-)-Proline, (2S)-pyrrolidine-2-carboxylic acid, (S)-Pyrrolidine-2-carboxylic acid, (-)-Proline, 2-pyrrolidinecarboxylic acid, (-)-(S)-Proline, (S)-2-Pyrrolidinecarboxylic acid
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
OriginProline is synthesized from glutamic acid or arginine through chemical reduction and cyclization processes. It is produced via fermentation of microorganisms or chemical synthesis from petrochemical-derived precursors.
2-Pyrrolidinecarboxylic acid, (S)-
Solubility 162000
Formula
C5H9NO2
Mol. Weight
115.13
CAS #
147-85-3, 609-36-9
Form
Powder
State
Dry Powder
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Eye Irritant
1 study / 1 not irritating (CIR 607)
Not a Skin Irritant
1 study / 1 not irritating (CIR 607)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 607)
Concentration Guide
Leave-on0.0001–2%
Rinse-off0.00001–1%
0%50%100%
CIR reported use · 2012 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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