Proline

AKA: L-proline, 147-85-3, L-(-)-Proline, (2S)-pyrrolidine-2-carboxylic acid, (S)-Pyrrolidine-2-carboxylic acid, (-)-Proline, 2-pyrrolidinecarboxylic acid, (-)-(S)-Proline, (S)-2-Pyrrolidinecarboxylic acid
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
2-Pyrrolidinecarboxylic acid, (S)-
Solubility 162000
Formula
C5H9NO2
Mol. Weight
115.13
CAS #
147-85-3, 609-36-9
Form
Powder
State
Dry Powder
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
An amino acid first isolated in 1901. While not traditionally used as a standalone ingredient, proline occurs naturally in skin collagen and has been studied for its role in skin structure and wound healing.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR