Propanediol

Propanediol 1
molecular structure · PubChem CID 10442
AKA: 26264-14-2, Propandiol, Coupling Lavender Relax Premium massagelotion, Coupling Chamomile Relax Premium massagelotion, 1, 3-PROPANEDIOL (USP-RS), FEMA NO. 4753
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Synthetic
Solvent
Clean
OriginDerived from petrochemical sources or synthesized from glycerin through chemical modification. Produced through hydrogenation and isomerization of glycerol or propylene glycol precursors.
Propanediol is a cosmetic ingredient used as solvent, viscosity controlling. Rated low hazard by EWG.
Formula
C3H8O2
Mol. Weight
76.09
CAS #
504-63-2, 26264-14-2
Form
Liquid
Skin Types
●all-skin-types, gentle
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Functions
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Viscosity Controlling
Dissolves Ingredients
Controls Viscosity
Antioxidant Protection
Reduces Inflammation
Fights Bacteria
Dissolves other ingredients
Controls product thickness
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 731)
Mixed Skin Irritation Results
3 studies / 1 irritating / 1 mixed / 1 not irritating / reactions mild (CIR 731)
Mixed Eye Irritation Results
1 study / 1 mixed / reactions slight (CIR 731)
Dermal Absorption 12%
human cadaver abdominal skin (stratum corneum n=6 from 3 donors) / in vitro static diffusion cell OECD TG 428 / Propanediol 1.059 g/mL (1200 uL/cm2 infinite dose) occluded / 48 hours (CIR 731)
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR