Propylene Glycol Dicaproate
molecular structure · PubChem
AKA: Propylene glycol dihexanoate, 50343-36-7, Sefsol 220, 1, 2-Propylene glycol dicaproate, 2-Propanediol dihexanoate, FEMA No. 4470
Synthetic
Emollient
Skin Conditioner
Plant Oil
Not Clean
Hexanoic acid, 1-methyl-1,2-ethanediyl ester
Effective at 1.0%
Solubility Practically insoluble or insoluble in water
Formula
C15H28O4
Mol. Weight
272.38
CAS #
50343-36-7
Form
Liquid
State
Clear colourless liquid; Mild fruity to green aroma
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Synthesized in the late 20th century as a propylene glycol diester. Adopted in contemporary cosmetics as a light emollient and texture enhancer, intended to replicate the feel and moisturizing properties of natural plant oils.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Restricted By
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
9.9e-05%
2.0%
0%14%
Reported use
CIR reported use: 0.000099-2
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR