Propylene Glycol Dicaproate

AKA: Propylene glycol dihexanoate, 50343-36-7, Sefsol 220, 1, 2-Propylene glycol dicaproate, 2-Propanediol dihexanoate, FEMA No. 4470
Synthetic
Emollient
Skin Conditioner
Not Clean
OriginDerived from propylene glycol and caproic acid (a saturated fatty acid from coconut or palm oils). Synthesized through esterification, where propylene glycol reacts with caproic acid under catalytic conditions.
Hexanoic acid, 1-methyl-1,2-ethanediyl ester
Solubility Practically insoluble or insoluble in water
Formula
C15H28O4
Mol. Weight
272.38
CAS #
50343-36-7
Form
Liquid
State
Clear colourless liquid; Mild fruity to green aroma
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2014
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR