Rhamnose
molecular structure · PubChem
AKA: 6-Deoxy-L-mannopyranose, (3R, 4R, 5R, 6S)-6-methyloxane-2, 3, 4, 5-tetrol, 6-deoxy-Mannose, Isodulcit, 6-Deoxy-Mannopyranose, 6-deoxy-mannopyranoside, 6-Deoxy-L-Mannopyranoside, CHEBI:16055, CHEBI:62345
Synthetic
Humectant
Sugar-Based Active
Clean
A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.
Effective at 5.0%
Formula
C6H12O5
Mol. Weight
164.16
CAS #
3615-41-6, 10030-85-0
Form
Powder
State
Solid
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
Traditional Use
A naturally occurring sugar first isolated from plant sources. Rhamnose was identified in the early 20th century and later incorporated into skincare for its humectant properties and potential to support skin barrier function.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.002%
10.0%
0%14%
Reported use
CIR reported use: 0.1-0.25 | 0.002-0.1 | 5-10
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR