Saccharide Isomerate
molecular structure · PubChem
AKA: Carbohydrate polymer, Humectant
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Synthetic
Humectant
Clean
Originthe stratum corneum of human skin. It binds to the free amino groups of lysine in the keratin of the stratum corneum, and cannot be washed off easily, leading to long-lasting moisturization (SkinInfo.
Saccharides, isomerised
CAS #
100843-69-4
Form
Liquid
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 815)
Not a Skin Irritant
11 studies / 11 not irritating (CIR 815)
Not a Sensitizer
6 studies / 6 not sensitizing (CIR 815)
Not an Eye Irritant
2 studies / 2 not irritating (CIR 815)
Concentration Guide
Leave-on0.001–2.8%
Rinse-off0.01–0.7%
0%50%100%
CIR reported use · 2018 survey
Regulatory Agencies
Verified Jun 2026
Data: CosIng · EWG · CIR
murphy