Sodium Isethionate

AKA: 1562-00-1, Isethionic acid sodium salt, Sodium 2-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, Monosodium salt, Sodium 2-hydroxyethylsulfonate, Sodium beta-hydroxyethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate
Synthetic
Cleanser
Skin Conditioner
Hair Care
Clean
OriginDerived from isethionic acid, a synthetic organic compound in the sulfonic acid family. Synthesized through the sulfonation of diethanolamine or ethanolamine followed by neutralization with sodium hydroxide.
Sodium 2-hydroxyethanesulphonate
Formula
C2H5NaO4S
Mol. Weight
148.12
CAS #
1562-00-1
Form
Liquid
State
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Antistatic
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 550)
Not an Eye Irritant
1 study / 1 not irritating (CIR 550)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 550)
Concentration Guide
Leave-on0.8%
Rinse-off2–6%
0%50%100%
CIR reported use · report published 2017
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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