Sodium Lauryl Sulfate

AKA: SODIUM SALT, FOR BIOCHEMISTRY, DODECYL SULFATE SODIUM SALT, LAURYL SULFATE SODIUM SALT
Synthetic
Cleanser
Emulsifier
Clean
OriginDerived from coconut or palm kernel oils, which contain lauric acid as a primary fatty acid. Synthesized through sulfonation of lauryl alcohol, followed by neutralization with sodium hydroxide.
Sodium lauryl sulfate (SLS) is an anionic surfactant used in many cleaning and hygiene products. It is naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity. The molecule has a tail of 12 carbon atoms, attached to a sulfate group, giving the molecule the amphiphilic properties required of a detergent. SLS is a highly effective surfactant used in any task requiring the removal of oily stains and residues. As such the compound is found in high concentrations in industrial products including engine degreasers, floor cleaners, and car wash soaps. In household products, SLS is used in lower concentrati
Formula
C12H25NaO4S
Mol. Weight
288.38
CAS #
151-21-3
Form
Powder
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Denaturant
Foaming
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Removes Impurities
Makes Alcohol Undrinkable
Creates Lather
Cleansing Surfactant
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe with qualifications (safe for brief use followed by thorough rinsing; leave-on/prolonged contact concentrations should not exceed 1%)
Pregnancy
Yes
Restricted By
CIR Safety Findings
Not a Sensitizer
4 studies / 4 not sensitizing / plus 1 case report (CIR 216)
Eye Irritant in Testing
19 studies / 19 irritating / reactions minimal to severe (CIR 216)
Mixed Skin Irritation Results
42 studies / 35 irritating / 4 mixed / 3 not irritating / reactions minimal to corrosive / plus 2 case reports (CIR 216)
Mixed Phototoxicity Results
Both phototoxic and non-phototoxic results in the CIR safety assessment (CIR 216)
Mixed Comedogenicity Results
Both comedogenic and non-comedogenic results in the CIR safety assessment (CIR 216)
Dermal Absorption 0.1%
guinea pig in vivo / radiolabeled SLS in water rubbed in 10 min then washed / 24 h nonocclusive patch / % of applied dose in urine (CIR 216)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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