Sodium PCA

Sodium PCA 1
molecular structure · PubChem CID 23668602
AKA: Sodium L-pyroglutamate, 28874-51-3, Sodium pyroglutamate, Sodium pidolate, L-Proline, Monosodium salt, L-5-Oxoproline monosodium salt, Sodium pyrrolidone-5-carboxylate, 5-Oxo-L-proline monosodium salt, Sodium L-pyrrolidonecarboxylate
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Synthetic
Humectant
Skin Conditioner
Hair Care
Clean
OriginDerived from L-pyroglutamic acid, a naturally occurring amino acid derivative within the pyroglutamate chemical family. Synthesized through acetylation and sodium salt formation of pyroglutamic acid precursors.
Sodium 5-oxo-2-pyrrolidinecarboxylate
Formula
C5H6NNaO3
Mol. Weight
151.10
CAS #
28874-51-3
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed4 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Reviewed by CIR
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Animal test and Human test found no phototoxicity in the CIR safety assessment (CIR 47 and 683)
Not Comedogenic
Animal test found no comedogenicity in the CIR safety assessment (CIR 47 and 683)
Not a Sensitizer
5 studies / 5 not sensitizing (CIR 47 and 683)
Mixed Eye Irritation Results
4 studies / 1 mixed / 3 not irritating / reactions mild (CIR 47 and 683)
Mixed Skin Irritation Results
10 studies / 2 mixed / 8 not irritating (CIR 47 and 683)
Dermal Absorption 1.08–6.78%
4 results from in vitro tests in the CIR safety assessment (CIR 47 and 683)
Concentration Guide
Leave-on0.00005–2.5%
Rinse-off0.0023–3%
0%50%100%
CIR reported use · 2014 survey
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR