Squalene

AKA: 111-02-4, Spinacene, Trans-Squalene, All-trans-Squalene, (6E, 10E, 14E, 18E)-2, 6, 10, 15, 19, 23-hexamethyltetracosa-2, 14, 18, 22-hexaene, Spinacen, Nikko Squalane EX, Super Squalene, 2, 23-Hexamethyl-2, 22-tetracosahexaene

Synthetic

Emollient

Skin Conditioner

Plant Oil

Barrier Lipid

Synthetic

Not Clean

Squalene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distributed in human tissues where it is transported in serum generally in association with very low density lipoproteins. Squalene is investigated as an adjunctive cancer therapy.

Effective at 5.5%

Solubility less than 1 mg/mL at 66 °F (NTP, 1992)

Formula

C30H50

Mol. Weight

410.70

CAS #

111-02-4

State

Trans-squalene is a clear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.

Functions

Emollient

Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.

Skin Conditioning

A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.

Reduces Static

Conditions Hair

Refatting

Conditions Skin

Traditional Use

Unable to provide traditional use description without a valid INCI or common name; this appears to be a CAS number without corresponding ingredient information.

EWG

CIR

Insufficient

Pregnancy

—

CIR Safety Findings

Not a Sensitizer

all-shades-safe

Concentration Guide

1.0%

10.0%

0%14%

Reported use

CIR reported use: .004-1.2 | .01-10

Regulatory Status

USAunder review

CANADA✔ permitted

Regulatory Agencies

EWG CIR FDA Health Canada

Skin Types

●all-skin-types

Best For

General

The paper trail

🔬Peer-reviewednone on file

⚖️Regulatory0 listings

🛡️Safety-assessed2 reviews →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

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