Sucrose Acetate Isobutyrate

AKA: SAIB, Sucrose acetoisobutyrate, Saccharose acetate isobutyrate, SAIB 100S, Diacetate hexaisobutyrate, Isobutyric acid, Hexaester with sucrose diacetate, INS NO.444, Alpha-D-Glucopyranoside, 6-O-acetyl-1, 3, 4-tris-O-(2-methyl-1-oxopropyl)-beta-D-fructofuranosyl, 6-acetate 2, 4-tris(2-methylpropanoate)
Plant-Derived
Occlusive
Clean
OriginDerived from sucrose (table sugar), a carbohydrate obtained from sugarcane or sugar beets. Produced through esterification of sucrose with isobutyric and acetic anhydrides.
Sucrose di(acetate) hexaisobutyrate
Formula
C40H62O19
Mol. Weight
846.90
CAS #
126-13-6
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Plasticiser
Anti-Aging
Antioxidant
Anti-Inflammatory
Creates protective layer
Adds flexibility
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
3 studies / 3 not sensitizing (CIR 721)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 721)
Mixed Skin Irritation Results
3 studies / 1 irritating / 2 not irritating / reactions slight (CIR 721)
Concentration Guide
Leave-on0.0084–31%
Rinse-off0.1%
0%50%100%
CIR reported use · report published 2021
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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