Tetramethyl Acetyloctahydronaphthalenes

AKA: OTNE, Iso E Super
Synthetic
Fragrance
Skin Conditioner
Not Clean
OriginSynthesized from polycyclic aromatic hydrocarbon precursors derived from petroleum or coal tar sources. Produced through catalytic hydrogenation and methylation reactions to create the stable tetramethyl-substituted naphthalene structure.
Mixture of isomers:1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one;1-(1,2,3,4,5,6,7,8-Octahydro-2,3,5,5-tetramethyl-2-naphthyl)ethan-1-one;1-(1,2,3,5,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one (68155-67-9); 1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one (68155-66-8)
CAS #
54464-57-2, 54464-59-4, 68155-66-8, 68155-67-9
Skin Types
●all-skin-types
Best For
General
Functions
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Insufficient
Pregnancy
—
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: CosIng · EWG · CIR