Tetrasodium EDTA

AKA: Sodium edetate, Edetate sodium, EDTA tetrasodium, EDTA sodium, Calsol, EDTA tetrasodium salt, Versene 100, Endrate tetrasodium, Sequestrene
Synthetic
Chelating Agent
Clean
OriginSynthesized from ethylenediamine and formaldehyde, derived from petrochemical or bio-based feedstocks. Produced through chelation reactions that bind the sodium salt to ethylenediaminetetraacetic acid precursors.
Tetrasodium ethylenediaminetetraacetate
Solubility Slightly soluble in ethanol
Formula
C10H12N2Na4O8
Mol. Weight
380.17
CAS #
64-02-8
Form
Powder
State
Dry Powder; Liquid; Other Solid; Dry Powder, Water or Solvent Wet Solid; NKRA; Pellets or Large Crystals; Dry Powder, Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Removes Metal Ions
Reduces Inflammation
Fights Bacteria
Wound Healing
Binds metal ions
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
2
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.002–0.5%
Rinse-off0.000002–1.9%
0%50%100%
CIR reported use · 2019 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR