Tetrasodium Glutamate Diacetate

Tetrasodium Glutamate Diacetate 1
molecular structure · PubChem CID 44630158
AKA: 51981-21-6, Tetrasodium N, N-Bis(carboxymethyl)-L-glutamate, N-bis(carboxylatomethyl)-L-glutamate, DISSOLVINE GL, CHELEST CMG-40
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the body duo
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the vitamin c and hyaluronic brightening duo
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Synthetic
Skin Conditioner
Synthetic
Clean
OriginDerived from glutamic acid and acetic acid, synthesized within the amino acid and organic acid chemical families. Produced through chelation synthesis, combining sodium salts of glutamate with acetate ligands via controlled chemical reaction.
Tetrasodium Glutamate Diacetate is a cosmetic ingredient. Also known as 51981-21-6. Rated low hazard by EWG.
Formula
C9H9NNa4O8
Mol. Weight
351.13
CAS #
51981-21-6
Form
Powder
State
Pellets or Large Crystals, Liquid; Dry Powder; Liquid
Skin Types
●all-skin-types
Best For
General
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Removes Metal Ions
Binds metal ions
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
2
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 798)
Mixed Skin Irritation Results
2 studies / 1 mixed / 1 not irritating / reactions slight (CIR 798)
Mixed Eye Irritation Results
1 study / 1 mixed / reactions minimal (CIR 798)
Concentration Guide
Leave-on0.0013–1%
Rinse-off0.037–0.31%
0%50%100%
CIR reported use · 2018 survey
Regulatory Status
USAunder review
CANADA✔ permitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR