Tetrasodium Glutamate Diacetate
AKA “51981-21-6, UNII-5EHL50I4MY, Tetrasodium N, N-Bis(carboxymethyl)-L-glutamate, 5EHL50I4MY, N-bis(carboxylatomethyl)-L-glutamate, EINECS 257-573-7, DISSOLVINE GL, CHELEST CMG-40, EC 257-573-7”
Synthetic
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Ingredient Facts
Tetrasodium glutamate diacetate
AKA: 51981-21-6, UNII-5EHL50I4MY, Tetrasodium N, N-Bis(carboxymethyl)-L-glutamate, 5EHL50I4MY, N-bis(carboxylatomethyl)-L-glutamate, EINECS 257-573-7, DISSOLVINE GL, CHELEST CMG-40, EC 257-573-7
Synthetic · Skin Conditioning · EWG: 2
Synthetic
Skin Conditioner
Amino Acid
Synthetic
Clean
Tetrasodium Glutamate Diacetate is a cosmetic ingredient. Also known as 51981-21-6. Rated low hazard by EWG.
Formula
C9H9NNa4O8
Mol. Weight
351.13
CAS #
51981-21-6
Form
Powder
State
Pellets or Large Crystals, Liquid; Dry Powder; Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Removes Metal Ions
Binds metal ions
Skin Types
●all-skin-types
Best For
General
Anti-Aging Hand Cream
COOLA
The New Tendency Complete Set
Nécessaire
beginner retinol gel 0.1%
Cocokind
calm & clarify duo
Cocokind
Everyday Radiance Essentials
Bloom Effects
Golden Hour Body Butter
Ursa Major
Golden Hour Body Serum
Ursa Major
holi (sun) spf 50 dewy tinted skin drops
Agent Nateur
The Hand Cream + The Tube Key
Nécessaire
holi (soleil) firming & plumping mineral spf 50 sunscreen
Agent Nateur
Hoppin’ Fresh Body Wash
Ursa Major
Super Serum Skin Tint SPF 30
ILIA Beauty
lactic acid cleanser duo
Agent Nateur
The New Tendency Duo
Nécessaire
peptide fine line eye gel
Cocokind
Radiance Reset
Bloom Effects
rise + shine trio
Cocokind
ReFresh Eye Brightener Broad Spectrum SPF 30 + Correcting Tint
RMS Beauty
SunCoverup Super Tint SPF 50
RMS Beauty
Brightening Bubbling Cleanser
Alpyn Beauty
Super Serum Skin Tint SPF 40
ILIA Beauty
The ILIA Look
ILIA Beauty
Daily SPF 50 Primer
Indie Lee
ReFresh Eye Brightener SPF 30 + Correcting Tint
RMS Beauty
SunCoverup Super Tint Broad Spectrum SPF 50 Sunscreen
RMS Beauty
Supernatural Radiance Serum Broad Spectrum SPF 30 Sunscreen
RMS Beauty
The Brighten Up Essentials
RMS Beauty
SOS Rescue Spray - Standard Size
Tower 28 Beauty
Golden Hour Body Butter
Credo Beauty
Golden Hour Body Serum
Credo Beauty
Forest Water Hyaluronic Serum
Ursa Major
Sunlit Essentials Set
Indie Lee
the after (glow) set: rose quartz
Agent Nateur
the after (glow) set: ruby
Agent Nateur
the body duo
Agent Nateur
the vitamin c and hyaluronic brightening duo
Agent Nateur
The Hand Duo
Nécessaire
The Hand-Lip Moisture Duo
Nécessaire
SOS Rescue Spray Party Pack
Tower 28 Beauty
GoGo Cooling Shimmer Eyeshadow
Tower 28 Beauty
Tulip Dew Sunscreen Serum
Bloom Effects
youthful duo
Cocokind
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Tetrasodium Glutamate Diacetate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR