murphyThiodipropionic Acid
AKA: 3'-Thiodipropionic acid, 111-17-1, Tyox A, TDPA, Propanoic acid, Bis(2-carboxyethyl) sulfide, Thiodihydracrylic acid, 4-Thiaheptanedioic acid, Sulfide, Bis(2-carboxyethyl)
Synthetic
Skin Conditioner
Acid
Clean
OriginSynthesized from acrylic acid and hydrogen sulfide, belonging to the organosulfur compound chemical family. Produced through condensation reaction of these precursors under controlled industrial conditions.
The CIR Expert Panel concludes that Dilauryl Thiodipropionate, Thiodipropionic Acid, Dicetyl Thiodipropionate, Dimyristyl Thiodipropionate, Distearyl Thiodipropionate, and Ditridecyl Thiodipropionate are safe as cosmetic ingredients in the practices of use and concentration given in this safety assessment when formulated to be non-irritating.
Solubility FREELY SOL IN HOT WATER, ALC, ACETONE; 1 G DISSOLVES IN 26.9 ML WATER @ 26 °C
Formula
C6H10O4S
Mol. Weight
178.21
CAS #
111-17-1
Form
Liquid
State
Dry Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Reviewed by CIR
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Human test found no phototoxicity in the CIR safety assessment (CIR 526)
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 526)
Not an Eye Irritant
1 study / 1 not irritating (CIR 526)
Mixed Skin Irritation Results
5 studies / 1 irritating / 1 mixed / 3 not irritating / reactions slight (CIR 526)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR