Tocopherol
AKA “8R*)]]-3, 4-DIHYDRO-2, 5, 8-TRIMETHYL-2-(4, 8
Antioxidant
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Ingredient Facts
Tocopherol
AKA: 8R*)]]-3, 4-DIHYDRO-2, 5, 8-TRIMETHYL-2-(4, 8
Antioxidant · Antioxidant · EWG: 2
Synthetic
Antioxidant
Skin Conditioner
Clean
Tocopherol exists in four different forms designated as α, β, δ, and γ. They present strong antioxidant activities, and it is determined as the major form of vitamin E. Tocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. The classification of the tocopherol molecules is designated depending on the number and position of the methyl substituent in the chromanol ring. The different types of tocopherol can be presented trimethylated, dimethylated or methylated in the positions 5-, 7- and 8-. When the carbons at position 5- and 7- are not methylated, they can function as electrophilic centers that can trap reactive oxygen and nitrogen species. Tocopherols can be found in the diet as part of vegetable oil such as corn, soybean, sesame, and cottonseed. It is currently under the list of substances generally recognized as safe (GRAS) in the FDA for the use of human consumption.
Formula
C28H48O2
Mol. Weight
416.70
CAS #
54-28-4, 16698-35-4, 10191-41-0, 119-13-1, 1406-18-4, 1406-66-2, 2074-53-5, 59-02-9, 7616-22-0
State
Liquid
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Neutralizes free radicals
Prevents moisture loss
Traditional Use
Appears to be a malformed or incomplete chemical identifier; unable to provide meaningful historical information without a valid CAS number or INCI name.
Skin Types
all-skin-types, gentle
Best For
General
EWG
2
CIR
Safe as used
Pregnancy
CIR Safety Findings
Not a Sensitizer
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
Dermal absorption: 1%. Source: CIR Safety Assessment (CIR Seq 667).
Regulatory Status
USApermitted
CANADApermitted
Regulatory Agencies
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Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilano
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Tocopherol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Tocopherol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Development of phospholipid nanoparticles encapsulating 3-O-cetyl ascorbic acid and tocopherol acetate (TA-Cassome) for improving their skin accumulat
Fushimi T, Uchino T, Miyazaki Y, Hatta I, Asano M et al.
International journal of pharmaceutics, 2018
Suppression of menthyl anthranilate (UV-A sunscreen)-sensitized singlet oxygen generation by Trolox and α-tocopherol.
Kitasaka S, Yagi M, Kikuchi A
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2020
Processing impact on tocopherols and triglycerides composition of soybean oil and its deodorizer distillate evaluated by high-performance liquid chrom
Laghari ZH, Sherazi STH, Ayyildiz HF, Topkafa M, Kara H et al.
Turkish journal of chemistry, 2020
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR