Tocophersolan

AKA: 2-Hydroxyethyl 2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-3, 4-dihydro-2H-1-benzopyran-6-yl butanedioate, 30999-06-5, Tocophersolan [USAN], Vitamin E TPGS, Tocofersolan (INN), Tocophersolan (USAN), 1-O-(2-hydroxyethyl) 4-O-[2, 4-dihydrochromen-6-yl] butanedioate
Synthetic
Antioxidant
Clean
OriginTocophersolan is synthesized from d-alpha-tocopherol, a naturally derived vitamin E compound, belonging to the tocopherol chemical family. It is produced through esterification of alpha-tocopherol with polyethylene glycol succinate.
Butanedioic acid, mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecy)-2H-1-benzopyran-6-yl] ester, polymer with oxirane (1:22)
Formula
C35H58O6
Mol. Weight
574.80
CAS #
30999-06-5
Form
Liquid
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed4 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 308)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 308)
Mixed Skin Irritation Results
2 studies / 1 irritating / 1 not irritating / reactions moderate (CIR 308)
Concentration Guide
CIR's newest survey reports no concentration of use.
CIR · 2013 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR