Tocopheryl Acetate

AKA: DL-alpha-Tocopherol acetate, 52225-20-4, All-rac-alpha-Tocopheryl acetate, (+-)-alpha-Tocopherol acetate, Alpha-tocopherol acetate, [2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-3, 4-dihydrochromen-6-yl] acetate, Dl-Alpha, Alpha-tocopheryl acetate
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Synthetic
Antioxidant
Skin Conditioner
Synthetic
Not Clean
OriginNative to Netherlands. Derived from tocopherol (vitamin E) and acetic acid through esterification synthesis. Produced by chemically bonding acetic acid to natural or synthetic tocopherol under catalytic conditions.
Vitamin E Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)
Formula
C31H52O3
Mol. Weight
472.70
CAS #
7695-91-2, 58-95-7
Form
Oil
State
Pellets or Large Crystals, Liquid; Pellets or Large Crystals
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Neutralizes free radicals
Prevents moisture loss
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Human test found no phototoxicity in the CIR safety assessment (CIR 308)
Mixed Eye Irritation Results
3 studies / 1 mixed / 2 not irritating / reactions weak to moderate (CIR 308 and 667)
Mixed Sensitization Results
5 studies / 1 sensitizing / 4 not sensitizing / plus 2 case reports (CIR 308 and 667)
Mixed Skin Irritation Results
10 studies / 2 mixed / 8 not irritating (CIR 308 and 667)
Dermal Absorption 1–18%
intact pig skin / in vitro OECD guideline 428 / 6 mg/cm2 of 5% [3H]-tocopheryl acetate cream in 1 of 3 AHA vehicles / 1 6 or 18 hours (CIR 667)
Concentration Guide
Leave-on0.00000001–36%
Rinse-off0.000075–10%
0%50%100%
CIR reported use · 2013 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR