Tocopheryl Acetate

AKA: DL-alpha-Tocopherol acetate, 52225-20-4, All-rac-alpha-Tocopheryl acetate, (+-)-alpha-Tocopherol acetate, Alpha-tocopherol acetate, [2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-3, 4-dihydrochromen-6-yl] acetate, Dl-Alpha, Alpha-tocopheryl acetate
Synthetic
Antioxidant
Skin Conditioner
Synthetic
Not Clean
Vitamin E Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)
Effective at 18.0%
Formula
C31H52O3
Mol. Weight
472.70
CAS #
7695-91-2, 58-95-7
Form
Oil
State
Pellets or Large Crystals, Liquid; Pellets or Large Crystals
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Neutralizes free radicals
Prevents moisture loss
Traditional Use
Vitamin E was identified in 1922; the acetate form was synthesized in the 1930s for improved stability in cosmetics. Became widely used in skincare and anti-aging products from the 1970s onward for its antioxidant properties.
EWG
3
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Concentration Guide
1e-08%
36.0%
0%100%
Reported use
CIR reported use: 0.0000009-5.4 | 0.001-2 | 0.00000001-36 | 0.001-36
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory0 listings
🛡️Safety-assessed3 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
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Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR