Tocopheryl Nicotinate

AKA: Vitamin E Nicotinate, 43119-47-7, Renascin, Vitamin E nicotinic acid ester, [(2R)-2, 5, 7, 8-tetramethyl-2-[(4R, 8R)-4, 8, 12-trimethyltridecyl]chroman-6-yl] pyridine-3-carboxylate, ((2R)-2, 8-tetramethyl-2-((4R, 12-trimethyltridecyl)chroman-6-yl) pyridine-3-carboxylate, Tocoferil nicotinate
Synthetic
Antioxidant
Skin Conditioner
Barrier Support
Clean
OriginDerived from vitamin E (tocopherol) and nicotinic acid, both naturally occurring compounds found in plant oils and seeds. Synthesized through esterification, chemically bonding tocopherol with nicotinic acid to create the hybrid compound.
[2R-[2R*(4R*,8R*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate / [2R*(4R*,8R*)]-(.+-.)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate
Formula
C35H53NO3
Mol. Weight
535.80
CAS #
16676-75-8, 43119-47-7, 51898-34-1, 86362-36-9
Form
Liquid
Skin Types
●all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Eye Irritant
1 study / 1 not irritating (CIR 308)
Not a Skin Irritant
2 studies / 2 not irritating (CIR 308)
Not a Sensitizer
1 study / 1 not sensitizing / plus 2 case reports (CIR 308 and 667)
Concentration Guide
Leave-on0.001%
Rinse-off0.1–1%
0%50%100%
CIR reported use · 2013 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
murphy