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Tocopheryl Succinate
AKA “4345-03-3, alpha-Tocopheryl succinate, alpha-tocopherol succinate, (+)-alpha-Tocopheryl succinate, d-alpha-Tocopherol acid succinate, Covitol 1210, alpha-Tocopheryl acid succinate, alpha-Vitamin E succinate, LU4B53JYVE, alpha-Tocopherol, succinate”
Antioxidant
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Ingredient Facts
Tocopheryl succinate
AKA: 4345-03-3, Alpha-Tocopheryl succinate, Alpha-tocopherol succinate, (+)-alpha-Tocopheryl succinate, D-alpha-Tocopherol acid succinate, Covitol 1210, Alpha-Tocopheryl acid succinate, Alpha-Vitamin E succinate, LU4B53JYVE, Alpha-Tocopherol
Antioxidant · Antioxidant · EWG: 4
Synthetic
Antioxidant
Plant Oil
Not Clean
.alpha.-Tocopheryl hydrogen succinate
Effective at 0.5%
Solubility less than 0.1 mg/mL at 64 °F (NTP, 1992)
Formula
C33H54O5
Mol. Weight
530.80
CAS #
4345-03-3, 17407-37-3
Form
Liquid
State
D-alpha-tocopheryl acid succinate is a white powder. (NTP, 1992)
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
Traditional Use
A synthetic ester of vitamin E developed for cosmetic applications. Created to stabilize vitamin E and enhance its antioxidant efficacy in skincare products.
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
1e-05%
1.0%
0%100%
Effective Range
CIR reported use: 0.0001-1 | 0.00001-0.038
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
RIFM fragrance ingredient safety assessment diethyl succinate, CAS Registry Number 123-25-1.
Api AM, Belsito D, Botelho D, Browne D, Bruze M et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018
→
RIFM fragrance ingredient safety assessment Dimethyl succinate, CAS Registry Number 106-65-0.
Api AM, Belsito D, Botelho D, Browne D, Bruze M et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018
→
Aluminum Starch Octenylsuccinate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Amended Final Report on the Safety Assessment of Dioctyl Sodium Sulfosuccinate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Aluminum Starch Octenylsuccinate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilano
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Trisodium Ethylenediamine Disuccinate and Tetrasodium Iminodisuccinate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Ammonium Dinonyl Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Calcium Starch Isododecenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Calcium Starch Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Castor isostearate beeswax succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cellulose Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Decyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diamyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dicapryl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dicapryl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dicetearyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diheptyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dihexyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diisobutyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diisobutyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dimethyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Pareth-1 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Pareth-2 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Sec-Pareth-12 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Sec-Pareth-3 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Sec-Pareth-5 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Sec-Pareth-7 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-14 Sec-Pareth-9 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium C12-15 Pareth Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Coceth-3 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Deceth-5 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Deceth-6 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Laneth-5 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Laureth Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Laureth-12 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Laureth-6 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Laureth-9 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Oleth-3 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ditridecyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glyceryl Stearate Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrolyzed Corn Starch Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxypropyl Methylcellulose Acetate/Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Magnesium Laureth-3 Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PEG-50 Hydrogenated Castor Oil Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyglyceryl-4 Laurate/Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyglyceryl-6 Palmitate/Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Potassium Cellulose Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Potassium Dextrin Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Potassium PEG-50 Hydrogenated Castor Oil Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Pumpkin Seed Oil Polyglyceryl-4 Esters Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Dextrin Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Hydrolyzed Potato Starch Dodecenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Hydroxypropyl Oxidized Starch Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Oxidized Starch Acetate/Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium PEG-50 Hydrogenated Castor Oil Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Starch Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
TEA-Dextrin Octenylsuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tetrasodium Iminodisuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tocopheryl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Ethylenediamine Disuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Developing a stable aqueous enteric coating formulation with hydroxypropyl methylcellulose acetate succinate (HPMCAS-MF) and colloidal silicon dioxide
Deshpande TM, Quadir A, Obara S, Ibrahim A, Hoag SW
International journal of pharmaceutics, 2018
→
Aluminum Starch Octenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Calcium Starch Octenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Castor isostearate beeswax succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dicapryl Sodium Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethyl Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dimethyl Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dioctyl Sodium Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Deceth-5 Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Deceth-6 Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Laureth Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Laureth-12 Sulfosuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydrolyzed Corn Starch Octenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Polyglyceryl-4 Laurate/Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Polyglyceryl-6 Palmitate/Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Hydrolyzed Potato Starch Dodecenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Starch Octenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tetrasodium Iminodisuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Ethylenediamine Disuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics.
Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA et al.
International journal of toxicology, 2016
→
Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics.
Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA et al.
International journal of toxicology, 2016
→
The surfactant Dioctyl Sodium Sulfosuccinate (DOSS) exposure causes adverse effects in embryos and adults of zebrafish (Danio rerio).
González-Penagos CE, Zamora-Briseño JA, Améndola-Pimenta M, Pérez-Vega JA, Montero-Muñoz J et al.
Toxicology and applied pharmacology, 2022
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR