Tocopheryl Succinate

AKA: 4345-03-3, Alpha-Tocopheryl succinate, Alpha-tocopherol succinate, (+)-alpha-Tocopheryl succinate, D-alpha-Tocopherol acid succinate, Covitol 1210, Alpha-Tocopheryl acid succinate, Alpha-Vitamin E succinate, Alpha-Tocopherol
Synthetic
Antioxidant
Plant Oil
Not Clean
.alpha.-Tocopheryl hydrogen succinate
Effective at 0.5%
Solubility less than 0.1 mg/mL at 64 °F (NTP, 1992)
Formula
C33H54O5
Mol. Weight
530.80
CAS #
4345-03-3, 17407-37-3
Form
Liquid
State
D-alpha-tocopheryl acid succinate is a white powder. (NTP, 1992)
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
Traditional Use
A synthetic ester of vitamin E developed for cosmetic applications. Created to stabilize vitamin E and enhance its antioxidant efficacy in skincare products.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
1e-05%
1.0%
0%100%
Reported use
CIR reported use: 0.0001-1 | 0.00001-0.038
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR