Triisopropanolamine

AKA: 122-20-3, TIPA, TRIS(2-HYDROXYPROPYL)AMINE, Tri-2-propanolamine, Tri-iso-propanolamine, Tris(2-propanol)amine, Tris(2-hydroxy-1-propyl)amine, 2-Propanol
Synthetic
Not Clean
OriginSynthesized from propylene oxide and ammonia, belonging to the alkanolamine chemical family. Produced through the reaction of ammonia with propylene oxide under controlled temperature and pressure conditions.
1,1',1''-Nitrilotripropan-2-ol
Solubility Soluble (NTP, 1992)
Formula
C9H21NO3
Mol. Weight
191.27
CAS #
122-20-3
Form
Liquid
State
Triisopropanolamine is a white solid with slight odor of ammonia. Denser than water.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Buffering
Stabilizes pH
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
7
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
3 studies / 3 not sensitizing (CIR 165 and 934)
Mixed Eye Irritation Results
6 studies / 5 irritating / 1 not irritating / reactions moderate to severe (CIR 165 and 934)
Mixed Skin Irritation Results
10 studies / 7 irritating / 1 mixed / 2 not irritating / reactions slight to moderate (CIR 165 and 934)
Concentration Guide
Leave-on0.000066–0.85%
Rinse-offNot reported
0%50%100%
CIR reported use · 2023 survey
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
🧂Conflict of interest.
Verified Jun 2026 · 🧪 = conflict
Data: PubChem · CosIng · EWG · CIR