Trimethylbenzoyl Diphenylphosphine Oxide

Trimethylbenzoyl Diphenylphosphine Oxide 1
molecular structure · PubChem CID 166480
AKA: 75980-60-8, Diphenyl(2, 4, 6-trimethylbenzoyl)phosphine oxide, 2, 6-trimethylbenzoyl diphenylphosphine oxide, CHIVACURE TPO, DOUBLECURE TPO
Synthetic
Skin Conditioner
Not Clean
OriginSynthesized from diphenylphosphine oxide and trimethylbenzoyl chloride precursors through phosphine oxide chemistry. Produced via coupling reaction of phosphine derivatives with benzoyl compounds under controlled conditions.
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
Solubility Water solubility: 3.3 mg/L at 20 °C (OECD Guideline 105, Flask method) and 11.9 mg/L at 20 °C (OECD Guideline 105, Column elution). Readily soluble in dichloromethane, acetone, n-butylacetate; soluble in styrene and in other monomers.
Formula
C22H21O2P
Mol. Weight
348.40
CAS #
75980-60-8
Form
Powder
State
NKRA; Pellets or Large Crystals, Liquid; Liquid; Dry Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
6
CIR
Insufficient data
Pregnancy
Caution
Concentration Guide
0%50%100%
Reg. limit 5%
EU/SCCS limit: 5% in cosmetic products. Opinion: SCCS/1528/14
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR