Tripeptide-1

AKA: Glycyl-l-histidyl-l-lysine, 49557-75-7, Prezatide, Liver cell growth factor, Glycyl-histidyl-lysine, Copper(II)ghk, KOLLAREN, ORISTAR GHK, Growth-modulating peptide (human)
Synthetic
Skin Conditioner
Barrier Support
Clean
OriginSynthesized from amino acids or amino acid precursors through peptide bond formation techniques in laboratory settings. Produced by coupling individual amino acids sequentially using solid-phase peptide synthesis or solution-phase methods.
Tripeptide-1 is a synthetic peptide containing glycine, histidine, and lysine
Formula
C14H24N6O4
Mol. Weight
340.38
CAS #
-
Form
Powder
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.00002–0.001%
Rinse-off0.00003%
0%50%100%
CIR reported use · 2014 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR