Trisodium Fructose Diphosphate

AKA: Fosfructose trisodium, 81028-91-3, Fosfructose trisodium [USAN], FOSFRUCTOSE TRISODIUM [MART.], FOSFRUCTOSE TRISODIUM [WHO-DD], D-Fructose 1, 6-bis(dihydrogen phosphate), Trisodium salt, Octahydrate, Trisodium fructose 1, 6-diphosphate octahydrate
Synthetic
Antioxidant
Chelating Agent
Not Clean
OriginDerived from fructose, a simple sugar typically sourced from corn, fruits, or sugarcane plants. Synthesized through phosphorylation of fructose using phosphoric acid or phosphate compounds under controlled conditions.
D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt, octahydrate
Formula
C6H27Na3O20P2
Mol. Weight
550.18
CAS #
81028-91-3
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Neutralizes Free Radicals
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2024
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR