Trisodium Glycyrrhizate

AKA: Trisodium glycyrrhizinate, Trisodium glycyrrhizin, CCRIS 9136, ORISTAR TSG, GLYCYRRHIZINATE, TRISODIUM GLYCYRRHIZATE VINYALS, Alpha-D-Glucopyranosiduronic acid, Trisodium salt
Synthetic
Skin Conditioner
Clean
20beta-Carboxy-11-oxo-30-nor-olean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alfa-D-glucopyranosiduronic acid, trisodium salt; Trisodium glycyrrhizate
Formula
C42H59Na3O16
Mol. Weight
888.90
CAS #
71277-78-6
Form
Powder
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice root (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine, Ayurveda, and ancient Egyptian medicine for over 3,000 years to soothe inflammation and irritated skin. The trisodium salt form is a modern extraction that concentrates licorice's anti-inflammatory properties.
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing
🛡️Safety-assessed3 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR