Urocanic Acid

AKA: 104-98-3, Urocaninic acid, 3-(1H-Imidazol-4-yl)-2-propenoic acid, (2E)-3-(1H-imidazol-4-yl)prop-2-enoic acid, 2-Propenoic acid, CHEBI:27248
Synthetic
Sunscreen Filter
Acid
Not Clean
OriginDerived from the imidazole compound family, urocanic acid is a naturally occurring metabolite of the amino acid histamine. Synthesized through chemical conversion of histamine or produced via microbial fermentation and subsequent purification processes.
2-Propenoic acid, 3-(1H-imidazol-4-yl)-
Solubility 1500
Formula
C6H6N2O2
Mol. Weight
138.12
CAS #
104-98-3
Form
Liquid
State
Solid
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
Functions
Uv Absorber
Blocks or absorbs UV rays to protect your skin from sun damage, dark spots, and premature aging.
Shields from UV damage
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Insufficient data
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 68)
Not a Sensitizer
3 studies / 3 not sensitizing (CIR 68)
Mixed Skin Irritation Results
10 studies / 5 irritating / 2 mixed / 3 not irritating / reactions minimal to mild (CIR 68)
Mixed Eye Irritation Results
4 studies / 3 irritating / 1 not irritating / reactions minimal to mild (CIR 68)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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