Vanillin

AKA: 4-Hydroxy-3-methoxybenzaldehyde, 121-33-5, Vanillic aldehyde, Vanillaldehyde, P-Vanillin, Vanilline, Lioxin, 3-Methoxy-4-hydroxybenzaldehyde, 4-Hydroxy-3-methoxy-benzaldehyde
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Synthetic
Fragrance
Synthetic
Not Clean
OriginSynthesized from guaiacol, a phenolic compound derived from wood pulp or petroleum feedstocks. Produced through oxidation of guaiacol using catalysts and oxidizing agents to form the aldehyde structure.
Vanillin is the primary component of the extract of the vanilla bean. Synthetic vanillin, instead of natural vanilla extract, is sometimes used as a flavouring agent in foods, beverages, and pharmaceuticals. It is used by the food industry as well as ethylvanillin.Artificial vanilla flavoring is a solution of pure vanillin, usually of synthetic origin. Because of the scarcity and expense of natural vanilla extract, there has long been interest in the synthetic preparation of its predominant component. The first commercial synthesis of vanillin began with the more readily available natural compound eugenol. Today, artificial vanillin is made from either guaiacol or from lignin, a constituent of wood which is a byproduct of the paper industry. (Wiki).
Solubility Slightly soluble (NTP, 1992)
Formula
C8H8O3
Mol. Weight
152.15
CAS #
121-33-5
Form
Powder
State
Vanillin appears as white or very slightly yellow needles.
Skin Types
●all-skin-types
Best For
General
Functions
Fragrance
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Insufficient
Pregnancy
—
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR