murphyPanthenol
AKA: DL-Panthenol, 16485-10-2, DL-Pantothenol, DL-Pantothenyl alcohol, Pantenol, Panthenolum, Racemic, Pantenolo, 2, 4-Dihydroxy-N-(3-hydroxypropyl)-3, 3-dimethylbutyramide
AHA Exfoliating Solution
Indie Lee
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Body Lotion
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Brand New Day Microderma Scrub + Masque
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Air Brow - Clear
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Air Brow
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Nécessaire
The Body Essentials
Nécessaire
Synthetic
Moisturizer
Skin Conditioner
B Vitamin
Clean
OriginPanthenol is derived from pantothenic acid (Vitamin B5), a member of the B-complex vitamin chemical family. It is synthesized through the reduction of pantothenic acid or its derivatives using chemical catalysts.
Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory form ([DB09357]) is biologically active. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and acce
Formula
C9H19NO4
Mol. Weight
205.25
CAS #
81-13-0, 16485-10-2
State
Liquid
Skin Types
●all-skin-types, gentle
Best For
General
Functions
Moisturizer
Adds or helps retain water in the skin. Could work as a humectant, emollient, or occlusive depending on the ingredient.
Lubricating Compound
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
—
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 737)
Not Comedogenic
Animal test and Product formulation test found no comedogenicity in the CIR safety assessment (CIR 168 and 737)
Mixed Sensitization Results
19 studies / 1 mixed / 18 not sensitizing / plus 12 case reports (CIR 168 and 737)
Mixed Eye Irritation Results
13 studies / 7 irritating / 3 mixed / 3 not irritating / reactions slight (CIR 168 and 737)
Mixed Skin Irritation Results
25 studies / 11 irritating / 3 mixed / 11 not irritating / reactions slight to severe (CIR 168 and 737)
Dermal Absorption 0.03–10%
human abdominal skin / in vitro Franz (static) diffusion cell / [14C]Panthenol 20 mg/ mL in ethanol 10 μl / receptor fluid collected up to 60 min post-application (CIR 737)
Concentration Guide
Leave-on0.0001–5.3%
Rinse-off0.000045–5%
0%50%100%
CIR reported use · 2016 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR