Tocopherol, Mixed

Tocopherol, Mixed molecular structure
molecular structure · PubChem
AKA: Vitamin E, Mixed Tocopherols, D-alpha-Tocopherol
Synthetic
Antioxidant
Skin Conditioner
Plant Oil
Not Clean
Tocopherol, Mixed is a cosmetic ingredient.
CAS #
54-28-4 (gamma)
Form
Liquid
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Neutralizes free radicals
Prevents moisture loss
Traditional Use
Vitamin E was discovered in 1922. Mixed tocopherols became popular in skincare and supplements starting in the 1950s for their antioxidant and skin-protective properties.
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
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Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
→
Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
→
Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other f
Hahn HJ, Jung HJ, Schrammek-Drusios MC, Lee SN, Kim JH et al.
Experimental and therapeutic medicine, 2016
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Effect of talc and vitamin E TPGS on manufacturability, stability and release properties of trilaurin-based formulations for hot-melt coating.
Huynh VT, de Paiva Lacerda S, Espitalier F, Beyssac E, Ré MI
International journal of pharmaceutics, 2024
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Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability.
Mohd Zaffarin AS, Ng SF, Ng MH, Hassan H, Alias E
International journal of nanomedicine, 2020
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Management of hot tar burn using vitamin e ointment containing petroleum and polyoxyethylene sorbitan.
Ng K, Dalen D, Rhine D
CJEM, 2013
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Effects of antioxidant capacity-based dietary replacement of vitamin E with commercial products containing grape skin-green tea extracts or hydrolyzed
Simoni M, Danese T, Mezzasalma N, Goi A, Pitino R et al.
Frontiers in veterinary science, 2025
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Electrospun chitosan//ethylcellulose-vitamin E//ethylcellulose-curcumin tri-chamber eccentric Janus nanofibers for a joint antibacterial and antioxida
Zhang Z, Xia Y, Gong W, Zhou J, Yu DG et al.
International journal of biological macromolecules, 2024
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Verified Jun 2026
Data: CosIng · EWG · CIR