Trisodium Phosphate

Trisodium Phosphate molecular structure
molecular structure · PubChem
AKA: 7601-54-9, Trisodium orthophosphate, Tromete, Tribasic sodium phosphate, Phosphoric acid trisodium salt, Phosphoric acid, Trisodium salt, Oakite, Anhydrous, Trinatriumphosphat
Synthetic
Chelating Agent
Clean
The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Trisodium Phosphate...
Effective at 0.28%
Solubility Freely soluble in water. Insoluble in ethanol
Formula
Na3O4P
Mol. Weight
163.94
CAS #
7601-54-9
Form
Powder
State
Sodium phosphate, tribasic appears as a colorless to white crystalline solid. Noncombustible.
Functions
Buffering
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Antioxidant
Boosts Collagen
Maintains optimal pH
Binds metal ions
Traditional Use
Developed in the 19th century as an industrial chemical; adopted by the cosmetics industry in the 20th century primarily as a pH buffer and chelating agent rather than for traditional skincare purposes.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.006%
0.56%
0%1%
Reported use
CIR reported use: 0.033-0.4 | 0.006-0.56
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR