Trisodium Phosphate

Trisodium Phosphate 1
molecular structure · PubChem CID 24243
AKA: 7601-54-9, Trisodium orthophosphate, Tromete, Tribasic sodium phosphate, Phosphoric acid trisodium salt, Phosphoric acid, Trisodium salt, Oakite, Anhydrous, Trinatriumphosphat
Synthetic
Chelating Agent
Clean
OriginProduced from phosphoric acid and sodium compounds through neutralization and crystallization processes. Synthesized by combining sodium hydroxide or sodium carbonate with phosphoric acid to form the trisodium salt.
The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Trisodium Phosphate...
Solubility Freely soluble in water. Insoluble in ethanol
Formula
Na3O4P
Mol. Weight
163.94
CAS #
7601-54-9
Form
Powder
State
Sodium phosphate, tribasic appears as a colorless to white crystalline solid. Noncombustible.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Buffering
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Antioxidant
Boosts Collagen
Maintains optimal pH
Binds metal ions
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Mixed Skin Irritation Results
6 studies / 2 irritating / 3 mixed / 1 not irritating / reactions minimal to slight (CIR 710)
Eye Irritant in Testing
4 studies / 4 irritating / reactions slight to corrosive (CIR 710)
Concentration Guide
Leave-on0.00045–7%
Rinse-off0.05–1.7%
0%50%100%
CIR reported use · 2015 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR