murphy2,4-Diaminophenol Dihydrochloride
AKA: Acrol, 4-Diaminophenol hydrochloride, 4-Diaminophenol HCl, Diamidophenol hydrochloride, Hydrochloride (1:2), NCI-C60026
Synthetic
Solvent
Not Clean
OriginSynthesized from phenylenediamine precursors within the aromatic amine chemical family. Produced through oxidative coupling and subsequent hydrochloride salt formation of aminophenol intermediates.
On the basis of the data included in this report, the CIR Expert Panel concludes that 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride are safe for use in hair dyes at concentrations up to 0.2% (as the free base). 2009 RE-REVIEW - The Expert Panel noted that 2,4-Diaminophenol Dihydrochloride is now termed 2,4-Diaminophenol Hydrochloride.
Solubility greater than or equal to 100 mg/mL at 74.3 °F (NTP, 1992)
Formula
C6H10Cl2N2O
Mol. Weight
197.06
CAS #
137-09-7
Form
Powder
State
Grayish-white crystals. (NTP, 1992)
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
Functions
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
2-Amino-4-nitrophenol.
IARC monographs on the evaluation of carcinogenic risks to humans, 1993
2-Amino-5-nitrophenol.
IARC monographs on the evaluation of carcinogenic risks to humans, 1993
4-amino-2-nitrophenol.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1978
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Mini reviews in medicinal chemistry, 2011
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Mini reviews in medicinal chemistry, 2011
Potential skin anti-aging effects of main phenolic compounds, tremulacin and tremuloidin from Salix chaenomeloides leaves on TNF-α-stimulated human de
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Chemico-biological interactions, 2024
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Dermatology reports, 2025
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Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final Amended Report on the Safety Assessment of p-Methylaminophenol Sulfate and p-Methylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Methylaminophenol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Amended Safety Assessment of 4-Chloro-2-Aminophenol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Sodium Benzotriazolyl Butylphenol Sulfonate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Tetrabromophenol Blue as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
2-Amino-6-Chloro-4-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Methyl-5-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
3-Nitro-p-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
4-Amino-3-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
4-Hydroxypropylamino-3-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Carvacrol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Chlorhexidine Dihydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
Sodium Acrylate/Acrolein Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Sodium Acrylates/Acrolein Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Sodium Benzotriazolyl Butylphenol Sulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Zinc Phenolsulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Amino-5-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Amino-6-Chloro-4-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
3-Nitro-p-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Amino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Hydroxypropylamino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Carvacrol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Chlorhexidine Dihydrochloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Sodium Benzotriazolyl Butylphenol Sulfonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Zinc Phenolsulfonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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Health Canada
Health Canada Cosmetic Ingredient Hotlist
2-Amino-4-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
2-Amino-5-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Amino-2-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Benzyloxyphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Ethoxyphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-tert-Butylphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4,4'-Isopropylidenediphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Dinitrophenol isomers
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Phenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Phenolphthalein
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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Current topics in medicinal chemistry, 2011
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Scientific reports, 2023
Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
Kim HH, Jeong SH, Park MY, Bhosale PB, Abusaliya A et al.
Scientific reports, 2023
Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
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Scientific reports, 2023
Analytical Method Development and Dermal Absorption of 4-Amino-3-Nitrophenol (4A3NP), a Hair Dye Ingredient under the Oxidative or Non-Oxidative Condi
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Toxics, 2024
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Journal of visualized experiments : JoVE, 2024
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Lingonberry (Vaccinium vitis-idaea L.) Fruit Phenolic Bio...
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International journal of toxicology, 2024
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Molecules (Basel, Switzerland), 2022
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Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR